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Apt. No. 1, First Floor, Abhishek Apartment, Near Shashwat Hospital, Opp. Paranjape Business Hub, Karve Road, Kothrud, Pune, Maharashtra 411038

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TARGETED THERAPY FOR CANCER TREATMENT

When Akshay s70 year old mother was diagnosed with breast cancer it had already spread to few of her bones. “ When I learnt my mother had stage 4 breast cancer I was worried as to how will she tolrate chemotherapy. But to my relief , my oncologist revealed that since my mother had a hormone positive breast cancer she can be treated with targeted drug Palbociclib with hormonal therapy. She is on oral tablets and is doing well for a year” This is how targeted therapy has helped avoid chemotherapy in some patients and has become the foundation of precision or personalised medicine.

Molecular targeted therapies are revolutionized cancer therapeutics. It refers to the use of drugs that targets specific molecules (molecular targets) to block the growth and spread of cancer cells. There are these specific genetic alterations that can distinguish cancer cells from normal cells and they can be used as molecular targets in the development of targeted drugs for cancer. Many molecular targeted therapies are now approved and have demonstrated remarkable clinical success in the treatment of various cancers like breast, leukemias, colorectal, lung, brain and ovarian cancers.

What are types of targeted therapies?

Agents used in molecular targeted therapy can be classified into small molecules, monoclonal antibodies, immunotherapeutic cancer vaccines and gene therapies.
How does targeted therapy work against cancer?
They treat cancer in many ways like: 

  • Help the immune cells to destroy cancer cells
  • Stop signals that help in formation of blood vessels.
  • Deliver cell-killing substances to cancer cells. (monoclonal antibodies)
  • Cause cancer cell death directly.
  • Starve cancer of the hormones it needs to grow. (breast and prostate
    cancers ).

Who will be given these targeted drugs?

Most patients with cancer will have a target for a certain drug, so they can be treated with that drug. But, before recommending targeted therapy, an oncologist will get your tumour tested to see if it contains targets for which targeted therapies are available. Testing your cancer for targets that could help you and your doctor choose your treatment is called biomarker testing which can be done on tumour tissue biopsy sample or blood sample which is called liquid biopsy.

What are side effects of Targeted therapy?

It does have some side effects like diarrhoea and liver problems being commonest. Other side effects might include problems with blood clotting and wound healing, high blood pressure, fatigue, mouth sores, nail changes, the loss of hair colour, and skin problems like a rash or dry skin.

How is targeted therapy given?

Small-molecule drugs are pills or capsules that you can swallow and Monoclonal antibodies are usually given through a needle in a blood vein.

Where is targeted therapy given?

Targeted therapy may be given at home in form of tablets or capsules. Some patients may receive targeted therapy in an outpatient daycare unit in a hospital.

To know whether targeted therapy is working or not, your oncologist will assess you for relief of symptoms, do blood tests and different types of scans to see your disease response.

Targeted therapy is the present and future of medical oncology with the aim of delivering personalised treatment to cancer patients.

 

DR RESHMA PURANIK
MD, DNB( Medicine), DM, DNB (Medical Oncology), MRCP (UK), ECMO